紅細胞在實驗性腦出血后腦水腫形成中的作用研究.pdf

1、蘇州大學碩士學位論文紅細胞在實驗性腦出血后腦水腫形成中的作用研究姓名：蔣輝華申請學位級別：碩士專業(yè)：神經病學指導教師：包仕堯2002.4.1。‘‘～3一l’Stu)ofErythroc、tes“EffectontheFormationofBrainEdemaaRerIntracereblralHemorrhageinRatsAbstract——StudyofErythrocytes’EffectOiltheFormationofBrai

2、nEdemaafterIntracerebralHemorrhageinRatsAbstractObjectiveNon—hepazinizedautohemicarterialbloodoftheratwasinjectedintoitscaudatenucleustoestablishamodelofintracerebralhemorrhageThechangesofedemainvariousregionsofthebrainw

3、eremeasuredatdifferenttimeafterhemorrhageMeanwhile，theeffectsoferythrocytesandthrombinonthefonnationofcerebraledemaaftercerebralhemorrhagewerestudiedtoexplorethepathophysi0109icalmechanismofcerebraledemaandtherolesoferyt

4、hrocytesandthrombininthisprocessMethodsNonhepal‘inizedautohemicbloodoftheratwastakenoutfromrat’Sfemoralafter)’andinjectedintoitscaudatenucleusimmediatelytoestablishamodelofintracerebralhemorrhageThechangesofedemaintheips

5、ilatez‘albassalganglia(A)，ipsilateralcortex(B)，contralateralbassalganglia(C)andcontralateralcortex(D)weremeasuredat1，23，5and7daysrespectivelyafterintracerebralhemorrhageTherat’Spackedredbloodcells，lysedredbloodcellsandhe

6、moglobinsatdifferentconcentrationswereinjectedrespectivelyintotherat’ScaudatenucleusThechangesofedemainvariousregionsofthebrainatdifferenttimeweremeasul’edasabove5Uthrombinwasinjectedintotherat’Scaudatenucleusandthechang