TGF-β上調(diào)miR-182表達抑制靶向CADM1促進膽囊癌轉移的研究.pdf

1、第二軍醫(yī)大學博士學位論文（同等學力）（同等學力）TGFβ上調(diào)miR182表達抑制靶向CADM1促進膽囊癌轉移的研究TGFβupregulatesmiR182expressiontopromotegallbladdercancermetastasisbytargetingCADM1研究生姓名：邱應和導師姓名：姜小清教授易濱副教授專業(yè)名稱：肝膽外科培養(yǎng)單位：第二軍醫(yī)大學第三附屬醫(yī)院第二軍醫(yī)大學第三附屬醫(yī)院二〇一四年四月目錄摘要.......

2、..................................................................................................................1Abstract.................................................................................................

3、....................5縮略詞表...................................................................................................................8前言.............................................................................

4、............................................9第一部分miR182在膽囊癌中的表達分析.....................................................21一、方法................................................................................................

5、..........21二、實驗結果..................................................................................................24三、討論..................................................................................................

6、......28第二部分TGFβ介導的miR182上調(diào)與GBC轉移相關研究結果.................30一、方法..........................................................................................................30二、討論..............................................

7、..........................................................46第三部分miR182通過靶向CADM1促進膽囊癌轉移分子機制研究............48一、方法..........................................................................................................48二、

8、實驗結果....................................................................................................52三、討論..........................................................................................................58四、

9、小結..........................................................................................................60綜述............................................................................................................